Antitumor agent-19
CAS No. 2379727-90-7
Antitumor agent-19 ( —— )
产品货号. M26058 CAS No. 2379727-90-7
Antitumor agent-19 is an antitumor agent targeting tumor-associated macrophages (TAMs) to serve as an effective TAMs modulator (EC50s: 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥2373 | 有现货 |
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5MG | ¥3629 | 有现货 |
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10MG | ¥5330 | 有现货 |
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25MG | ¥7995 | 有现货 |
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50MG | ¥11178 | 有现货 |
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100MG | ¥15309 | 有现货 |
|
500MG | ¥30618 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Antitumor agent-19
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Antitumor agent-19 is an antitumor agent targeting tumor-associated macrophages (TAMs) to serve as an effective TAMs modulator (EC50s: 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells).
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产品描述Antitumor agent-19 is an antitumor agent targeting tumor-associated macrophages (TAMs) to serve as an effective TAMs modulator (EC50s: 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells).(In Vitro):In RAW 264.7 cells, Antitumor agent-19 (10 μM, 20 μM, or 50 μM) effectively and dose-dependently induces the expression of M1-phenotype macrophage markers including IL-1β, TNF-α, iNOS and IL-12α. Antitumor agent-19 dose-dependently repolarizes tumor-associated macrophages from M1 (anti-tumor) and M2 (pro-tumor).(In Vivo):In C57BL/6 female mice with lewis lung cancer cells, Antitumor agent-19 (5 mg/kg; i.p.) remarkably inhibits tumor growth. The synergy of Antitumor agent-19 with anti-PD-1 antibody shows more superior antineoplastic effects in vivo.
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同义词——
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通路Others
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靶点Other Targets
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受体Endogenous Metabolite
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研究领域——
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适应症——
化学信息
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CAS Number2379727-90-7
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分子量487.9
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分子式C24H21ClF3N5O
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纯度>98% (HPLC)
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溶解度——
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SMILESCn1cc(cn1)-c1cccc2[nH]c3CCC(Cc3c12)NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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